منابع مشابه
Recruitment of NAADP-sensitive acidic Ca2+ stores by glutamate.
NAADP (nicotinic acid-adenine dinucleotide phosphate) is an unusual second messenger thought to mobilize acidic Ca(2+) stores, such as lysosomes or lysosome-like organelles, that are functionally coupled to the ER (endoplasmic reticulum). Although NAADP-sensitive Ca(2+) stores have been described in neurons, the physiological cues that recruit them are not known. Here we show that in both hippo...
متن کاملNAADP induces pH changes in the lumen of acidic Ca2+ stores.
NAADP (nicotinic acid-adenine dinucleotide phosphate)-induced Ca2+ release has been proposed to occur selectively from acidic stores in several cell types, including sea urchin eggs. Using fluorescence measurements, we have investigated whether NAADP-induced Ca2+ release alters the pH(L) (luminal pH) within these acidic stores in egg homogenates and observed their prompt, concentration-dependen...
متن کاملStaphylococcal leukotoxins trigger free intracellular Ca2+ rise in neurones, signalling through acidic stores and activation of store-operated channels
Headache, muscle aches and chest pain of mild to medium intensity are among the most common clinical symptoms in moderate Staphylococcus aureus infections, with severe infections usually associated with worsening pain symptoms. These nociceptive responses of the body raise the question of how bacterial infection impinges on the nervous system. Does S. aureus, or its released virulence factors, ...
متن کاملSynaptic [Ca2+] Intracellular Stores Spill Their Guts
The last decade has seen numerous advances in optical techniques that have allowed the study of neuronal [Ca 2ϩ ] dynamics with increasing spatial and temporal resolution in relatively intact preparations, including brain slices. Particularly exciting has been the measure-A critical role of Ca 2ϩ in neuronal signaling is to couple ment of synaptic [Ca 2ϩ ] transients in dendrites and electrical...
متن کاملMitochondria sensitive to ER Ca2+ stores
n page 993, Bucciarelli et al. report the first evidence that chromosomes are not always necessary for proper spindle assembly and cell division. The authors stumbled upon chromosome-independent cell division during a screen for meiosis mutants in Drosophila. Two of the mutants they identified, fusolo and solofuso , had chromosome segregation defects that led to secondary spermato-cytes lacking...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Messenger
سال: 2016
ISSN: 2167-955X
DOI: 10.1166/msr.2016.1054